RO-275

Overview

RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC 50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > HCN Channel

Product Information

• Catalog No.: HY-160505
• CAS No.: 2648837-04-9
• Molecular Formula: C18H14ClN5O
• Molecular Weight: 351.79
• Purity: 99.95%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 0.5 mg/mL (1.42 mM); Clear solution
• Availability: In-stock

Source

Original product source