Neutrophil elastase-IN-7 (Compound 12) is an effective inhibitor of neutrophil elastase ( HNE ), with an IC 50 value of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against various coagulation proteins, with the IC 50 values for thrombin , FXa , FXIa , and FXIIIa being 8.2, 12.7, 1.2, and 5.7 μM, respectively. Neutrophil elastase-IN-7 can be used for research on inflammation, innate immune responses, and tissue remodeling.
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