ELOVL6-IN-5

Overview

ELOVL6-IN-5 is an orally active and selective elongase enzyme of long-chain fatty acid family 6 (ELOVL6) inhibitor with IC 50 values of 85 nM and 38 nM for human and mouse ELOVL6, respectively. ELOVL6-IN-5 shows >60-fold selectivity over other ELOVL family enzymes ( ELOVL1 , 2, 3, 5) and no effect on other lipid synthesis enzymes like ACC1 , ACC2 . ELOVL6-IN-5 reduces hepatic fatty acid composition ratio of C18 to C16 in diet-induced obesity (DIO) and KKAy mice. ELOVL6 inhibition by ELOVL6-IN-5 does not improve insulin resistance. ELOVL6-IN-5 can be used for the research of metabolic disease .

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > ELOVL

Product Information

• Catalog No.: HY-160912
• CAS No.: 1135000-36-0
• Molecular Formula: C20H20F3N3O3S
• Molecular Weight: 439.45
• Purity: 95.47%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.69 mM); Clear solution
• Availability: In-stock

Source

Original product source