PROTAC Chk1 degrader-1

Overview

PROTAC Chk1 degrader-1 is a Chk1 -targeting PROTAC .PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1 . PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect. PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma. (Pink: Chk1 Target protein ligand; Blue: Cereblon ligand ( HY-103597 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Melanoma | Products > Disease Areas > Metastatic Melanoma | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Checkpoint Kinase (Chk)

Product Information

• Catalog No.: HY-161108
• CAS No.: 2597167-34-3
• Molecular Formula: C43H44N14O9
• Molecular Weight: 900.90
• Purity: 99.70%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source