APP degrader-1

Overview

APP degrader-1 (Compound 0152) is an orally active amyloid precursor protein ( APP ) degrader that induces APP degradation and reduces the extracellular release of Aβ42 . APP degrader-1 can bind to both CAPRIN1 and APP , and enhances their interaction as well as CAPRIN1-mediated APP degradation through the endosome-lysosome pathway.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Amyloid-β

Product Information

• Catalog No.: HY-161110
• CAS No.: 3090769-17-5
• Molecular Formula: C20H20N4O4S
• Molecular Weight: 412.46
• Purity: 99.11%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution
• Availability: In-stock

Source

Original product source