JNJ-39758979

Overview

JNJ-39758979, a chemical probe, is a selective, orally active, and high-affinity histamine H 4 receptor antagonist with K i s of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H 4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity.

Application

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Product Information

• Catalog No.: HY-101189
• CAS No.: 1046447-90-8
• Molecular Formula: C11H19N5
• Molecular Weight: 221.31
• Purity: 98.75%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 3.5 mg/mL (15.82 mM); Clear solution
• Availability: In-stock

Source

Original product source