Cilengitide

Overview

Cilengitide (EMD 121974) is a BBB-permeable integrins antagonist with IC 50 s of 0.61 nM ( α ν β 3 ), 8.4 nM ( α ν β 5 ) and 14.9 nM ( α 5 β 1 ), respectively. Cilengitide inhibits the binding of α ν β 3 and α ν β 5 to Vitronectin with IC 50 s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis , shows antiangiogenic effect in the research against glioblastoma and other cancers.

Application

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Product Information

• Catalog No.: HY-16141
• CAS No.: 188968-51-6
• Molecular Formula: C27H40N8O7
• Molecular Weight: 588.66
• Purity: 99.91%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: 100 mg/mL (169.88 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source