Cilengitide (Standard)

Overview

Cilengitide (Standard) is the analytical standard of Cilengitide. This product is intended for research and analytical applications. Cilengitide (EMD 121974) is a BBB-permeable integrins antagonist with IC50s of 0.61 nM (ανβ3), 8.4 nM (ανβ5) and 14.9 nM ( α5β1 ), respectively. Cilengitide inhibits the binding of ανβ3 and ανβ5 to Vitronectin with IC50s of 4 nM and 79 nM, respectively. Cilengitide inhibits TGF-β/Smad signaling, mediates PD-L1 expression. Cilengitide also induces apoptosis , shows antiangiogenic effect in the research against glioblastoma and other cancers.

Application

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Product Information

• Catalog No.: HY-16141R
• CAS No.: 188968-51-6
• Molecular Formula: C27H40N8O7
• Molecular Weight: 588.66
• Purity: 98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source