SIK-IN-2

Overview

SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase ( SIK ), which inhibits SKI1, SIK2 and SIK3 with IC 50 s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC 50 of 0.5 nM, stimulates the LPS ( HY-D1056 ) -induced IL-10 release with EC 50 of 2 nM in human macrophages.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > AMPK

Product Information

• Catalog No.: HY-161441
• CAS No.: 3033846-20-4
• Molecular Formula: C22H22N6OS
• Molecular Weight: 418.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source