JTT-654

Overview

JTT-654 is an orally active, potent and selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. The IC 50 of JTT-654 for 11β-HSD1 is 4.65, 0.97, and 0.74 nM in human, rat, and mouse recombinant enzymes , respectively. JTT-654 showed competitive inhibition against human recombinant enzyme. The IC 50 value for human 11β-HSD2 is > 30 μM (human 11β-HSD2 is responsible for the reverse reaction against human 11β-HSD1). JTT-654 ameliorates insulin resistance and non-obese type 2 diabetes by inhibiting adipose tissue and liver 11β-HSD1.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > 11β-HSD

Product Information

• Catalog No.: HY-161449
• CAS No.: 916828-66-5
• Molecular Formula: C28H33F3N4O3
• Molecular Weight: 530.58
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source