DCLK1-IN-5 (Compound a24) is a DCLK1 inhibitor (IC 50 : 179.7 nM). DCLK1-IN-5 inhibits lipopolysaccharide ( HY-D1056 )-induced inflammation via inhibiting DCLK1-mediated IKKβ phosphorylation. DCLK1-IN-5 protects mice against inflammation-induced lung injury and sepsis.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Ser/Thr Protease
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