SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a K i of 1.78 nM and an IC 50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC 50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment.
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