DW18134

Overview

DW18134 is an inhibitor for interleukin receptor-associated kinase 4 ( IRAK 4 ) with an IC 50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK , downregulates the secretion of TNF-α and IL-6 . DW18134 attenuates the Lipopolysaccharides ( HY-D1056 )-induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function .

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > IRAK

Product Information

• Catalog No.: HY-161620
• CAS No.: 2626988-87-0
• Molecular Formula: C24H21N5O3
• Molecular Weight: 427.46
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source