PROTAC EGFR degrader 11

Overview

PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor ( EGFR ), with DC 50 <100 nM. PROTAC EGFR degrader 11 binds CRBN-DDB1 with a K i of 36 nM. PROTAC EGFR degrader 11 degrades EGFR , focal adhesion kinase ( FAK ), and RSK1 , inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC 50 <100 nM.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > FAK

Product Information

• Catalog No.: HY-161633
• CAS No.: 3034244-71-5
• Molecular Formula: C49H64ClFN10O7S
• Molecular Weight: 991.61
• Purity: 99.20%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source