PROTAC FLT3/CDKs degrader-1

Overview

PROTAC FLT3/CDKs degrader-1 is a PROTAC degrader targeting CDKs and FLT3 . PROTAC FLT3/CDKs degrader-1 degrades CDK2 , CDK4 , CDK6 , CDK9 and FLT3 proteins via a ubiquitin-proteasome-dependent bivalent mechanism, with a DC 50 of 18.73 nM against CDK2 . PROTAC FLT3/CDKs degrader-1 promotes myeloid cell differentiation. PROTAC FLT3/CDKs degrader-1 inhibits leukemia cell proliferation. PROTAC FLT3/CDKs degrader-1 can be used for the research of acute myeloid leukemia. (Pink: FLT3 and CDK2 and CDK4 and CDK6 and CDK9 ligand ( HY-161709 ); Blue: Cereblon ligand ( HY-W087383 ); Black: linker ( HY-W012935 )).

Application

Products | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > CDK | Products > Signaling Pathways > FLT3

Product Information

• Catalog No.: HY-161708
• CAS No.: 3075001-08-7
• Molecular Formula: C40H42N12O5
• Molecular Weight: 770.84
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source