XYD129

Overview

XYD129 is a CBP/p300 PROTAC degrader. XYD129 potently binds to CBP , p300 and CRBN proteins, with IC 50 values of 0.021 μM, 0.03 μM and 0.18 μM, respectively. XYD129 forms a ternary CRBN - CBP / p300 complex and induces CBP / p300 degradation via the ubiquitin-proteasome system. XYD129 inhibits tumor growth and suppresses the proliferation of acute myeloid leukemia cells. XYD129 can be used in studies related to acute myeloid leukemia. (Pink: CBP and p300 ligand ( HY-161711 ); Blue: Cereblon ligand ( HY-41547 ); Black: linker ( HY-40178 )).

Application

Products | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > Histone Acetyltransferase

Product Information

• Catalog No.: HY-161710
• CAS No.: 3056017-73-0
• Molecular Formula: C41H39FN8O9
• Molecular Weight: 806.79
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source