P2Y14R antagonist 1

Overview

P2Y14R antagonist 1 (compound I-17) is a selective P2Y14R antagonist with an IC 50 of 0.6 nM. It exhibits potent P2Y14R antagonistic activity, both in vitro and in vivo efficacy, and favorable pharmacokinetic profiles. P2Y14R antagonist 1 reduces the release of inflammatory factors and cell pyroptosis through the NOD-like receptor family pyrin domain-containing 3 ( NLRP3 )/gasdermin D (GSDMD) signaling pathway. P2Y14R antagonist 1 holds promise for research in the field of acute gouty arthritis.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Depression | Products > Disease Areas > Autoimmune Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > P2Y Receptor | Products > Signaling Pathways > NOD-like Receptor (NLR)

Product Information

• Catalog No.: HY-161727
• CAS No.: 2728291-29-8
• Molecular Formula: C15H12BrN3O2
• Molecular Weight: 346.18
• Purity: 98.76%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (14.44 mM); Clear solution
• Availability: In-stock

Source

Original product source