Anle138b-F105

Overview

Anle138b-F105 is an autophagy-targeting chimera ( AUTOTAC ) that targets p62/Sequestosome-1/SQSTM1 . Anle138b-F105 binds to the ZZ domain of p62 , induces conformational activation, self-oligomerization, interaction with LC3, and formation of autophagosomes. Anle138b-F105 induces autophagic flux of ubiquitin-conjugated aggregated proteins, leading to their lysosomal degradation. Anle138b-F105 is applicable for the research of neurodegenerative proteinopathies.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Autophagy | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > AUTOTACs | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-161746
• CAS No.: 2941386-44-1
• Molecular Formula: C36H37FN4O5
• Molecular Weight: 624.70
• Purity: 98.18%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (8.00 mM); Clear solution
• Availability: In-stock

Source

Original product source