RG100204

Overview

RG100204 is a selective, orally available inhibitor of the aquaporin AQP9 . RG100204 directly inhibits AQP9 channel function, preventing the transmembrane transport of water, glycerol, and H 2 O 2 . RG100204 reduces the activation of the NLRP3 inflammasome and p38 MAPK signaling pathways, thereby alleviating inflammation and pyroptosis . RG100204 reduces multi-organ dysfunction in a mouse sepsis model and shows glucose-regulating effects in diabetic db/db mice.

Application

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Product Information

• Catalog No.: HY-161834
• CAS No.: 2140901-88-6
• Molecular Formula: C20H26N6O2S2
• Molecular Weight: 446.59
• Purity: 99.50%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source