PROTAC GPX4 degrader-2

Overview

PROTAC GPX4 degrader-2 is a cIAP -recruiting GPX4 PROTAC degrader with a DC 50 of 1.68 μM. PROTAC GPX4 degrader-2 forms a ternary complex with GPX4 and cIAP , and induces GPX4 degradation via the ubiquitin-proteasome system pathway. PROTAC GPX4 degrader-2 induces Mitochondrial depolarization and Ferroptosis . PROTAC GPX4 degrader-2 exhibits antiproliferative effects in cancer cells. PROTAC GPX4 degrader-2 can be used for the research of fibrosarcoma. (Pink: GPX4 ligand ( HY-175903 ); Blue: IAP ligand ( HY-137159 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > SNIPERs | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > IAP

Product Information

• Catalog No.: HY-162106
• CAS No.: 3035509-76-0
• Molecular Formula: C50H61ClN8O9
• Molecular Weight: 953.52
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source