COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2 , 15-LOX , and mPGES-1 enzymes with IC 50 values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments.
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