COX-1-IN-1 (compound 15a) is a selective inhibitor for cyclooxygenase ( COX ), with IC 50 s of 0.23 μM ( COX-1 ) and >50 μM ( COX-2 ), selective index ( COX-2 IC 50 /COX-1 IC 50 ) is 217. COX-1-IN-1 inhibits platelet aggregation.
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