PROTAC BTK Degrader-9

Overview

PROTAC BTK Degrader-9 is a potent BTK PROTAC degrader with a DC 50 of 1.29 nM (in Mino cells at 4 h). PROTAC BTK Degrader-9 induces the formation of a stable ternary complex with BTK and the CRBN E3 ubiquitin ligase , thereby mediating proteasomal degradation of BTK in a CRBN -dependent manner. PROTAC BTK Degrader-9 downregulates the RANKL -activated BTK - PLCγ2 -Ca 2+ - NFATc1 signaling pathway. PROTAC BTK Degrader-9 alleviates alveolar bone resorption in periodontitis models of Mus musculus (house mouse). PROTAC BTK Degrader-9 can be used in research related to periodontitis. (Pink: Btk ligand ( HY-175909 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-W209253 )).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > RANKL/RANK | Products > Signaling Pathways > Nuclear Factor of activated T Cells (NFAT) | Products > Signaling Pathways > Btk

Product Information

• Catalog No.: HY-162280
• CAS No.: 3034024-77-3
• Molecular Formula: C46H52FN13O5
• Molecular Weight: 885.99
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source