PROTAC SOS1 degrader-6

Overview

PROTAC SOS1 degrader-6 is a selective SOS1 PROTAC degrader with a DC 50 of 43-130 nM. PROTAC SOS1 degrader-6 induces ubiquitination and degradation of SOS1 via the ubiquitin-proteasome system by recruiting the E3 ligase VHL . PROTAC SOS1 degrader-6 reduces the levels of phosphorylated MEK and ERK . PROTAC SOS1 degrader-6 exerts antiproliferative effects in KRAS-driven cancer cells. PROTAC SOS1 degrader-6 can be used in research related to KRAS G12C -mutant cancers and chronic myeloid leukemia. (Pink: SOS1 ligand ( HY-169371 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-W016456 )).

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Chronic Myelogenous Leukemia | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SOS1 | Products > Signaling Pathways > MEK | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-162281
• CAS No.: 3032282-51-9
• Molecular Formula: C46H55F3N8O6S
• Molecular Weight: 905.04
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source