Nrf2 degrader 1

Overview

Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with a DC 50 of 0.1-1 μM in huH1 cells. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC 50 values of 100 nM and 40 nM, respectively. Nrf2 degrader 1 can be used for the study of liver cancer , non-small cell lung cancer (NSCLC) and squamous cell carcinoma of lung cancer . (Pink: Nrf2 Target protein ligand; Blue: Cereblon ligand ( HY-41547 ); Black: linker).

Application

Products | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Lung Squamous Cell Carcinoma | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > NF-κB | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Keap1-Nrf2

Product Information

• Catalog No.: HY-162307
• CAS No.: 3025286-00-1
• Molecular Formula: C45H42N6O8S
• Molecular Weight: 826.92
• Purity: 98.77%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.02 mM); Clear solution
• Availability: In-stock

Source

Original product source