Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine ( HY-N6691 )-induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity.
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