Influenza A virus-IN-14 (Compound 37) is an inhibitor for influenza virus type A ( IAV ), which inhibits H1N1 with an EC 50 of 23 nM. Influenza A virus-IN-14 exhibits low cytotoxicity with CC 50 of more than 100 μM. Influenza A virus-IN-14 inhibits cytopathic effect and improves the survival rates of cell Calu3. Influenza A virus-IN-14 exhibits synergistic activity with the neuraminidase inhibitor Oseltamivir ( HY-13317 ). Influenza A virus-IN-14 exhibits poor pharmacokinetic properties in CD-1 mouse.
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