LYP-8

Overview

LYP-8 is an intracellular nicotinamide phosphoribosyltransferase (iNAMPT) inhibitor with an IC 50 of 0.76 μM, a reducing agent, and a tumor growth inhibitor. LYP-8 recruits VHL E3 ligase to induce iNAMPT polyubiquitination and proteasome-dependent degradation, and inhibits iNAMPT enzymatic activity. LYP-8 reduces eNAMPT levels by degrading iNAMPT to decrease eNAMPT secretion. LYP-8 reduces intracellular NAD + levels in cancer cells and proinflammatory cytokine levels ( IL-6 , TNF-α) in tumor tissue and serum. LYP-8 can be used for the research of colon cancer . (Pink: NAMPT ligand ( HY-50876 ); Blue: VHL ligand ( HY-112078 ); Black: linker ( HY-128801 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > NAMPT

Product Information

• Catalog No.: HY-162537
• CAS No.: 2484876-99-3
• Molecular Formula: C56H74N8O10S
• Molecular Weight: 1051.30
• Purity: 99.89%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.38 mM); Clear solution
• Availability: In-stock

Source

Original product source