LC-MI-3

Overview

LC-MI-3 is an orally active IRAK4 degrader with an IC 50 of 57.2 nM and high selectivity among human protein kinases.LC-MI-3 eliminates IRAK4 kinase and scaffolding functions via the cereblon E3 ubiquitin ligase and ubiquitin-proteasome systems.LC-MI-3 inhibits downstream nuclear factor-κB and IRAK4 -mediated inflammatory signaling pathways.LC-MI-3 exerts anti-inflammatory activity in lipopolysaccharide-, Escherichia coli -, TLR4-, and TLR7-induced inflammatory models.LC-MI-3 can be used for the research of acute lung injury, sepsis, psoriasis, and inflammatory diseases. (Pink: IRAK4 ligand ( HY-179095 ); Blue: Cereblon ligand ( HY-W023573 ); Black: linker).

Application

Products | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Psoriasis | Products > Disease Areas > Sepsis | Products > Disease Areas > Acute Lung Injury | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > PROTAC | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > IRAK | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-162538
• CAS No.: 3053823-69-8
• Molecular Formula: C39H36N8O8
• Molecular Weight: 744.75
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source