REM127

Overview

REM127 is an orally active, blood-brain barrier-penetrant septin 6/7 molecular glue degrader. REM127 binds to SEPT6 with high affinity and promotes the assembly of SEPT2/6/7 cortical filaments, thereby normalizing cytoplasmic calcium levels, cerebrospinal fluid hyperphosphorylated tau protein levels, synaptic function and cognitive function. REM127 can be used in research related to Alzheimer's disease.

Application

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Product Information

• Catalog No.: HY-162566
• CAS No.: 1417823-67-6
• Molecular Formula: C20H20Cl2N4S
• Molecular Weight: 419.37
• Purity: 99.18%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1.25 mg/mL (2.98 mM); Clear solution
• Availability: In-stock

Source

Original product source