MC-ND-18

Overview

MC-ND-18 is an ATTEC degrader that degrades NLRP3 via the Autophagy pathway, with a DC 50 of 125.5 nM in THP-1 cells. MC-ND-18 exhibits anti-inflammatory activity in a DSS-induced mouse model of colitis. MC-ND-18 can be used for research on inflammatory bowel disease. MC-ND-18 consists of an NLRP3 inhibitor ( HY-156121 ), a linker ( HY-W018745 ), and an LC3 ligand.

Application

Products | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Inflammatory Bowel Disease | Products > Disease Areas > Colitis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Autophagy | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > ATTECs | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-162588
• CAS No.: 3081572-53-1
• Molecular Formula: C42H42Br2IN3O9S
• Molecular Weight: 1051.58
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source