CDK8-IN-15

Overview

CDK8-IN-15 (Compound 46) is a potent CDK8 inhibitors with an IC 50 value of 57 nM. It can enhance the thermal stability of CDK8 along with inhibition against NF-κB and have favourable selectivity across the CDK family and tyrosine kinase. Additionally, it also demostrates a positive effect in vitro psoriasis model induced by TNF-α and alleviats the inflammatory response enhancing the expression of Foxp3 and IL-10 , which is promising for research of psoriasis diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-162600
• CAS No.: 2988020-03-5
• Molecular Formula: C19H20N4O3
• Molecular Weight: 352.39
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source