PROTAC JAK1 degrader 1

Overview

PROTAC JAK1 degrader 1 is a JAK1 PROTAC degrader with a DC 50 of 214 nM and an IC 50 of 5.2 nM. PROTAC JAK1 degrader 1 inhibits the downstream JAK-STAT signaling pathway by degrading JAK1 . PROTAC JAK1 degrader 1 exhibits antiproliferative activity in cells. PROTAC JAK1 degrader 1 can be used for research on leukemia. (Pink: JAK1 ligand ( HY-10961 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > STAT | Products > Signaling Pathways > JAK

Product Information

• Catalog No.: HY-162608
• CAS No.: 3052553-20-2
• Molecular Formula: C44H41N9O6
• Molecular Weight: 791.85
• Purity: 99.97%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (3.16 mM); Clear solution
• Availability: In-stock

Source

Original product source