FGFR2 degrader 1 (compound 28E) is a selectively PROTACS degrader of FGFR2 , with the DC 50 of 0.645 nM. FGFR2 plays an important role in cancer research (Pink: ligand of target protein; ( HY-13304 ) black: linker; blue: ligand of E3 ligase ). (Pink: FGFR2 ligand ( HY-13304 ); Blue: Cereblon ligand ( HY-W087383 ); Black: linker).
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