TIC10g

Overview

TIC10g is a dual inhibitor for toll-like receptor 7 and 9 ( TLR7 and TLR9 ), which inhibits TLR7 and TLR9 mediated TNF-α release in mouse macrophages ( IC 50 is 14.5 μM and 6.5 μM) and human B lymphocytes ( IC 50 is 7.69 μM and 11.5 μM). TIC10g inhibits the activation of NF-κB and MAPK, and exhibits anti-inflammatory activity against systemic lupus erythematosus and rheumatoid arthritis .

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-162649
• CAS No.: 754998-88-4
• Molecular Formula: C20H21N3O4
• Molecular Weight: 367.40
• Purity: 98.92%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.80 mM); Clear solution
• Availability: In-stock

Source

Original product source