SLF80821178 hydrochloride is an orally active inhibitor for sphingosine-1-phosphate transporter (Spns2) , that inhibits the sphingosine-1-phosphate (S1P) release in HeLa with an IC 50 of 51 nM. SLF80821178 hydrochloride reduces the circulating lymphocyte without affecting plasma S1P levels in mice.
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