(S)-PHA533533

Overview

(S)-PHA533533 is a CDK2 and CDK5 inhibitor with blood-brain barrier permeability, with IC 50 values of 37 nM and 55 nM, respectively. (S)-PHA533533 effectively restores UBE3A expression by downregulating UBE3A-ATS and relieving the epigenetic silencing of paternal UBE3A in mature neurons. (S)-PHA533533 can be used for the research of Angelman syndrome.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > CDK | Products > Signaling Pathways > E1/E2/E3 Enzyme

Product Information

• Catalog No.: HY-162683
• CAS No.: 437982-89-3
• Molecular Formula: C19H22N4O2
• Molecular Weight: 338.40
• Purity: 98.27%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (7.39 mM); Clear solution
• Availability: In-stock

Source

Original product source