LSD1-IN-34

Overview

LSD1-IN-34 (Compound 7d) is the orally active inhibitor for Lysine-specific demethylase (LSD) and monoamine oxidase (MAO) , with IC 50 of 4.51 and 18.46 nM, for LSD1 and MAO A . LSD1-IN-34 inhibits the Ang II-induced neonatal rat myocardial fibroblasts (NRCFs) activation, without significant toxicity (20 μM). LSD1-IN-34 inhibits TGFβ/Smad signaling pathway, and ameliorates heart failure in mice. LSD1-IN-34 exhibits good pharmacokinetic characteristics in rats.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Histone Demethylase | Products > Signaling Pathways > Monoamine Oxidase | Products > Signaling Pathways > TGF-beta/Smad

Product Information

• Catalog No.: HY-162729
• CAS No.: 3048029-74-6
• Molecular Formula: C19H17ClF2N4O2
• Molecular Weight: 406.81
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source