OPB-171775

Overview

OPB-171775 is an orally active molecular glue. OPB-171775 forms ternary complex with phosphodiesterase 3A ( PDE3A ) and schlafen family member 12 ( SLFN12 ). OPB-171775 causes SLFN12 RNase-mediated cell death, activates SLFN12 RNase-associated GCN2 signaling pathway. OPB-171775 exhibits significant efficacy against gastrointestinal stromal tumor.

Application

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Product Information

• Catalog No.: HY-162730
• CAS No.: 2131210-15-4
• Molecular Formula: C15H18F2N2O3
• Molecular Weight: 312.31
• Purity: 99.80%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source