ZJCK-6-46

Overview

ZJCK-6-46 (32) is a potential and orally active DYRK1A inhibitor (IC 50 = 0.68 nM) with high BBB permeability (CNS+). ZJCK-6-46 (32) reduces tau phosphorylation. ZJCK-6-46 (32) ameliorates cognitive dysfunction by obviously reducing the expression of phosphorylated tau and neuronal loss in vivo .

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > DYRK | Products > Signaling Pathways > Tau Protein

Product Information

• Catalog No.: HY-162750
• CAS No.: 3096805-18-1
• Molecular Formula: C24H21N5O
• Molecular Weight: 395.46
• Purity: 99.06%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (12.64 mM); Clear solution
• Availability: In-stock

Source

Original product source