COMT-IN-1

Overview

COMT-IN-1 (compound C12), a nitrophenolic analogue, is an orally active dopamine metabolic enzyme catechol-O-methyltransferase ( COMT ) inhibitor with IC 50 s of 0.37 μM, 95.58 μM and 58.82 μM for COMT , MAO-A and MAO-B , respectively. COMT-IN-1 exhibits chelation with a variety of metal ions. COMT-IN-1 exhibits good BBB permeability. COMT-IN-1 improves dopamine levels and ameliorates MPTP ( HY-15608 )-induced Parkinson's disease (PD) symptoms in mice.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > COMT | Products > Signaling Pathways > Monoamine Oxidase

Product Information

• Catalog No.: HY-162760
• CAS No.: 2987884-27-3
• Molecular Formula: C24H18FN3O6
• Molecular Weight: 463.41
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source