PROTAC SMARCA2/4 degrader-27

Overview

PROTAC SMARCA2/4 degrader-27 is a VHL-recruiting PROTAC degrader targeting SMARCA2 and SMARCA4 , derived from structure-guided modification of PROTAC SMARCA2/4 degrader-28 ( HY-162835 ). PROTAC SMARCA2/4-degrader-27 forms a cooperative ternary complex with CRL2 VHL E3 ligase to induce ubiquitination and degradation. PROTAC SMARCA2/4-degrader-27 induces a novel protein-protein interaction between VHL and SMARCA2/SMARCA4, thereby stabilizing ternary complex formation and promoting proteasomal degradation of target proteins. PROTAC SMARCA2/4-degrader-27 exhibits enhanced cell permeability and stronger ternary complex formation ability, leading to improved degradation activity. PROTAC SMARCA2/4-degrader-27 can be used in cancer-related research [1] . (Pink: SMARCA2 and SMARCA4 ligand ( HY-44012 ); Blue: VHL ligand ( HY-125905 ); Black: linker ( HY-159678 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SWI/SNF Complex

Product Information

• Catalog No.: HY-162834
• CAS No.: 2375564-54-6
• Molecular Formula: C49H58FN9O6S
• Molecular Weight: 920.10
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source