MS7829 is a deubiquitinase-targeting chimera (DUBTAC) that targets cGAS . MS7829 recruits OTUB1 to cGAS , binds covalently to OTUB1 , stabilizes the protein abundance of cGAS , and activates the cGAS - STING - IRF3 innate immune signaling pathway in an OTUB1 -dependent manner. MS7829 is applicable to cancer-related research.
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > DUBTACs | Products > Signaling Pathways > STING | Products > Signaling Pathways > Cyclic GMP-AMP Synthase
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