PROTAC PD-L1 degrader-2

Overview

PROTAC PD-L1 degrader-2 is a PD-L1 PROTAC degrader with an IC 50 of 197.4 nM and a K d of 301 nM. PROTAC PD-L1 degrader-2 induces PD-L1 endocytosis, drives degradation via the proteasomal and lysosomal pathways, and inhibits the PD-1 / PD-L1 interaction. As an immune activator, PROTAC PD-L1 degrader-2 increases the levels of CD4 + , CD8 + , granzyme B and perforin. PROTAC PD-L1 degrader-2 can be used in studies related to colon cancer immunology. (Pink: PD-1/PD-L1 ligand ( HY-162973 ); Blue: Cereblon ligand ( HY-W867704 ); Black: linker ( HY-128833 )).

Application

Products | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer Immunology | Products > Disease Areas > Immunotherapy for Colorectal Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Colorectal Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > PD-1/PD-L1

Product Information

• Catalog No.: HY-162972
• CAS No.: 2995357-09-8
• Molecular Formula: C46H42ClFN6O8
• Molecular Weight: 861.31
• Purity: 95.23%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source