EGR-1-IN-1

Overview

EGR-1-IN-1 is a EGR-1 inhibitor with an IC 50 of 1.86 μM. EGR-1-IN-1 binds to the zinc finger DNA-binding domain of EGR-1 and promotes the dissociation of the EGR-1 -DNA complex. EGR-1-IN-1 reduces the mRNA expression levels of EGR-1 -regulated inflammatory genes induced by TNFα. EGR-1-IN-1 alleviates atopic dermatitis-like lesions in the ear skin of mice. EGR-1-IN-1 serves as a lead compound for the development of targeted compounds for inflammatory skin diseases. EGR-1-IN-1 can be used in studies related to atopic dermatitis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Allergy | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Atopic Dermatitis | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > DNA Methyltransferase | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-163731
• CAS No.: 3077196-25-6
• Molecular Formula: C17H13N5O2S
• Molecular Weight: 351.38
• Purity: 99.07%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source