PROTAC PD-L1 degrader-1

Overview

PROTAC PD-L1 degrader-1 is a CRBN -based PD-L1-PROTAC degrader with a notable PD-L1 protein degradation capability. PROTAC PD-L1 degrader-1 shows potent PD-L1 degradation in 4T1 cells with a DC 50 of 0.609 μM. PROTAC PD-L1 degrader-1 can be used for the study of breast cancer . (Pink: PD-1/PD-L1 ligand ( HY-19745 ); Blue: Cereblon ligand ( HY-150839 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > PD-1/PD-L1

Product Information

• Catalog No.: HY-163757
• CAS No.: 3052114-77-6
• Molecular Formula: C45H55N5O7
• Molecular Weight: 777.95
• Purity: 99.79%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (3.21 mM); Clear solution
• Availability: In-stock

Source

Original product source