HuR degrader 2

Overview

HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-binding protein Hu antigen R ( HuR ) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC 50 ≤200 nM. HuR degrader 2 exhibits a high affinity with cereblon , with an HTRF ratio < 0.02.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > HuR

Product Information

• Catalog No.: HY-163759
• CAS No.: 3040301-46-7
• Molecular Formula: C20H15N3O3
• Molecular Weight: 345.35
• Purity: 98.47%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (14.48 mM); Clear solution
• Availability: In-stock

Source

Original product source