CSNK2-IN-1 is a potent and selective CSNK2 inhibitor with IC 50 of 1.7 nM and 0.66 nM for CSNK2A1 and CSNK2A2 , respectively. CSNK2-IN-1 has antiviral activity against beta-coronaviruses such as SARS-CoV-2 and MHV. CSNK2-IN-1 has good solubility, metabolic stability, and low cytotoxicity, but its plasma concentration in vivo decreases rapidly and is insufficient to achieve pharmacological effects. CSNK2-IN-1 can be used in the research of antiviral drug development.
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