UNI418

Overview

UNI418 is a dual inhibitor of PIKfyve and PIP5K1C with antiviral activity against SARS-CoV-2 ( EC 50 =1.4 μM). UNI418 blocks ACE2-mediated SARS-CoV-2 viral endocytosis by inhibiting PIP5K1C ( IC 50 =60.1 nM; K d =61 nM). In addition, UNI418 inhibits the proteolytic activation of proteases regulated by PIKfyve ( K d =0.78 nM) to prevent SARS-CoV-2 from entering host cells.

Application

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Product Information

• Catalog No.: HY-163943
• CAS No.: 1802068-51-4
• Molecular Formula: C22H16N6
• Molecular Weight: 364.40
• Purity: 99.61%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source