JNK-IN-17

Overview

JNK-IN-17 (Compound 9J) is a selective and potent JNK inhibitor with IC 50 values of 0.039, 0.079 μM for JNK1 and JNK3 . JNK-IN-17 can inhibit c-Jun phosphorylation with an IC 50 of 0.082 μM in Streptozotocin ( HY-13753 )-infuced INS-1 pancreatic islet β cells. JNK-IN-17 shows inhibition rate ≤ 33% on the four main P450 subtypes (2C9, 2D6, 3A4, 1A2) in human liver microsomes, indicating a relatively low risk of drug interactions. JNK-IN-17 can be used for researches of neurological and metabolic disease , such as Parkinson's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > JAK

Product Information

• Catalog No.: HY-164111
• CAS No.: 1128096-58-1
• Molecular Formula: C28H23N9O
• Molecular Weight: 501.54
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source